When Sekai gets sick and asks Setsuna to take over for her at her part-time job at Cafe Radish, Setsuna takes the job even though she doesn't like the revealing uniforms and has no experience as a waitress. She only continues because she learns that Makoto lives nearby; it’s the chance for Setsuna has been secretly hoping for: a chance to start something special with Makoto. However, instead of seeing Makoto more often, she has an unfortunate accident during her first meeting with Inori, who ends up becoming her roommate.
School Days focuses on the life of Makoto Ito, a first-year high school student living with his divorced and unseen mother in the fictional city of Haramihama. During his second term, he becomes infatuated with Kotonoha Katsura, a soft-spoken schoolmate who shares train rides with him to and from campus. When his homeroom seating plan is rearranged, he becomes acquaintances with Sekai Saionji, an upbeat girl who takes a special interest in his newfound crush, befriending the two and providing them the grounds to meet. In spite of her triumphant efforts however, Sekai becomes jealous of the new couple, having developed feelings for Makoto herself.